Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas

Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas.

Medical treatment of adult soft tissue sarcomas is more and more dictated by the histological subtype, in a family of rare cancers made up of dozens of these subsets. This applies to both cytotoxics and target therapies. In addition to doxorubicin and ifosfamide, therefore, there is evidence of efficacy of gemcitabine in leiomyosarcomas; trabectedin in leiomyosarcomas and liposarcomas, with an ...

Histology-driven chemotherapy of soft-tissue sarcoma.

Soft-tissue sarcomas are rare diseases with >50 subtypes. Surgery is the most important treatment in localized disease, sometimes combined with radiotherapy. Chemotherapy is used as palliation in advanced disease, sometimes also with a potential to decrease tumour size and eradicate micro-metastases, making meaningful surgery possible. The role of chemotherapy as adjuvant treatment in localized...

3d-histology and Malignant Soft Tissue Sarcomas of the Skin

Systemic Therapy for Advanced Soft Tissue Sarcomas

Soft tissue sarcomas (STS) are a rare, heterogeneous group of solid tumors in need of improved therapeutic options. First-line chemotherapy is considered the current standard of care for patients with advanced, symptomatic STS, but the median survival is only 8 to 12 months. Efforts to increase response rates by using combination or dose-dense regimens have largely failed to improve patient out...

[Treatment of bone and soft tissue sarcomas].

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